Dual Anti-cancer and Anti-Itch Activity of PD176252 Analogues: Design, Synthesis and Biological Evaluation.
Identifieur interne : 000871 ( Main/Exploration ); précédent : 000870; suivant : 000872Dual Anti-cancer and Anti-Itch Activity of PD176252 Analogues: Design, Synthesis and Biological Evaluation.
Auteurs : Ming-Jun Yu [République populaire de Chine] ; Sen Yao [République populaire de Chine] ; Ting-Ting Li [République populaire de Chine] ; Rui Yang [République populaire de Chine] ; Ri-Sheng Yao [République populaire de Chine]Source :
- Anti-cancer agents in medicinal chemistry [ 1875-5992 ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux, Antinéoplasiques (), Antinéoplasiques (pharmacologie), Antinéoplasiques (synthèse chimique), Antiprurigineux (), Antiprurigineux (pharmacologie), Antiprurigineux (synthèse chimique), Cellules cancéreuses en culture, Conception de médicament, Femelle, Humains, Indoles (), Indoles (pharmacologie), Indoles (synthèse chimique), Lignées consanguines de souris, Mâle, Prolifération cellulaire (), Prurit (traitement médicamenteux), Relation dose-effet des médicaments, Relation structure-activité, Souris, Structure moléculaire, Tests de criblage d'agents antitumoraux.
- MESH :
- pharmacologie : Antinéoplasiques, Antiprurigineux, Indoles.
- synthèse chimique : Antinéoplasiques, Antiprurigineux, Indoles.
- traitement médicamenteux : Prurit.
- Animaux, Antinéoplasiques, Antiprurigineux, Cellules cancéreuses en culture, Conception de médicament, Femelle, Humains, Indoles, Lignées consanguines de souris, Mâle, Prolifération cellulaire, Relation dose-effet des médicaments, Relation structure-activité, Souris, Structure moléculaire, Tests de criblage d'agents antitumoraux.
English descriptors
- KwdEn :
- Animals, Antineoplastic Agents (chemical synthesis), Antineoplastic Agents (chemistry), Antineoplastic Agents (pharmacology), Antipruritics (chemical synthesis), Antipruritics (chemistry), Antipruritics (pharmacology), Cell Proliferation (drug effects), Dose-Response Relationship, Drug, Drug Design, Drug Screening Assays, Antitumor, Female, Humans, Indoles (chemical synthesis), Indoles (chemistry), Indoles (pharmacology), Male, Mice, Mice, Inbred Strains, Molecular Structure, Pruritus (drug therapy), Structure-Activity Relationship, Tumor Cells, Cultured.
- MESH :
- chemical , chemical synthesis : Antineoplastic Agents, Antipruritics, Indoles.
- chemical , chemistry : Antineoplastic Agents, Antipruritics, Indoles.
- chemical , pharmacology : Antineoplastic Agents, Antipruritics, Indoles.
- drug effects : Cell Proliferation.
- drug therapy : Pruritus.
- Animals, Dose-Response Relationship, Drug, Drug Design, Drug Screening Assays, Antitumor, Female, Humans, Male, Mice, Mice, Inbred Strains, Molecular Structure, Structure-Activity Relationship, Tumor Cells, Cultured.
Abstract
Cancer patients treated with targeted anti-cancer drug suffer from itch or pruritus. Itch or pruritus is an unpleasant sensation that brings about a negative impact on quality of life, and serious itch may lead to dose reduction and even discontinuation. Gastrin releasing peptide receptor (GRPR) plays a critical role in itch, inflammation and cancer, and GRPR antagonist has obvious effect on cancer, inflammation and itch. The aim of this paper is to develop a new agent with anti-cancer and anti-itch activity.
DOI: 10.2174/1871520619666190408133141
PubMed: 30961511
Affiliations:
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souris</term><term>Mâle</term><term>Prolifération cellulaire ()</term><term>Prurit (traitement médicamenteux)</term><term>Relation dose-effet des médicaments</term><term>Relation structure-activité</term><term>Souris</term><term>Structure moléculaire</term><term>Tests de criblage d'agents antitumoraux</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Antineoplastic Agents</term><term>Antipruritics</term><term>Indoles</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antineoplastic Agents</term><term>Antipruritics</term><term>Indoles</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antineoplastic Agents</term><term>Antipruritics</term><term>Indoles</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Proliferation</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Pruritus</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antinéoplasiques</term><term>Antiprurigineux</term><term>Indoles</term></keywords><keywords scheme="MESH" qualifier="synthèse chimique" xml:lang="fr"><term>Antinéoplasiques</term><term>Antiprurigineux</term><term>Indoles</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Prurit</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dose-Response Relationship, Drug</term><term>Drug Design</term><term>Drug Screening Assays, Antitumor</term><term>Female</term><term>Humans</term><term>Male</term><term>Mice</term><term>Mice, Inbred Strains</term><term>Molecular Structure</term><term>Structure-Activity Relationship</term><term>Tumor Cells, Cultured</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Antinéoplasiques</term><term>Antiprurigineux</term><term>Cellules cancéreuses en culture</term><term>Conception de médicament</term><term>Femelle</term><term>Humains</term><term>Indoles</term><term>Lignées consanguines de souris</term><term>Mâle</term><term>Prolifération cellulaire</term><term>Relation dose-effet des médicaments</term><term>Relation structure-activité</term><term>Souris</term><term>Structure moléculaire</term><term>Tests de criblage d'agents antitumoraux</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cancer patients treated with targeted anti-cancer drug suffer from itch or pruritus. Itch or pruritus is an unpleasant sensation that brings about a negative impact on quality of life, and serious itch may lead to dose reduction and even discontinuation. Gastrin releasing peptide receptor (GRPR) plays a critical role in itch, inflammation and cancer, and GRPR antagonist has obvious effect on cancer, inflammation and itch. The aim of this paper is to develop a new agent with anti-cancer and anti-itch activity.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Anhui</li></region><settlement><li>Hefei</li></settlement></list><tree><country name="République populaire de Chine"><region name="Anhui"><name sortKey="Yu, Ming Jun" sort="Yu, Ming Jun" uniqKey="Yu M" first="Ming-Jun" last="Yu">Ming-Jun Yu</name></region><name sortKey="Li, Ting Ting" sort="Li, Ting Ting" uniqKey="Li T" first="Ting-Ting" last="Li">Ting-Ting Li</name><name sortKey="Yang, Rui" sort="Yang, Rui" uniqKey="Yang R" first="Rui" last="Yang">Rui Yang</name><name sortKey="Yao, Ri Sheng" sort="Yao, Ri Sheng" uniqKey="Yao R" first="Ri-Sheng" last="Yao">Ri-Sheng Yao</name><name sortKey="Yao, Sen" sort="Yao, Sen" uniqKey="Yao S" first="Sen" last="Yao">Sen Yao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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